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March 31, 2015
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New biomarker for IBS?

An experimental antibody test might identify patients with diarrhea-predominant IBS. Irritable bowel syndrome (IBS) is described as a “functional disorder,” meaning that it has no known biological basis.

Animal studies have shown that Campylobacter jejuni infection can precipitate an IBS-like condition and that a bacterial toxin called cytolethal distending toxin B (CdtB) might be responsible. If the results of this large study are replicated in other patients with IBS, doctors might have a simple blood test to confirm the diagnosis of D-IBS and to distinguish it from inflammatory bowel disease, celiac sprue and other conditions.

See: Pimentel M et al., PLoS ONE 2015 May 13; 10:e0126438

David Robbins
David Robbins